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Aging of Wound Healing in an Experimental Model in Mice.

Hiss, Jehuda M.D.; Hirshberg, Abraham M.D., D.M.D.; Dayan, Dan Fundoiano D.M.D., M.Sc.; Bubis, Jose J. M.D.; Wolman, Moshe M.D.
American Journal of Forensic Medicine & Pathology: December 1988
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Healing of incised wounds in the backs of mice was studied to establish criteria that would allow the timing of stages during cutaneous wound healing. Starting from day 4 after the incisions were made, three mice were killed every 3 days until day 40. Sections from wounds were stained with hematoxylin-eosin, a reticulin procedure, and picrosirius red. Unstained sections were used for blue autofluorescence. The significance of the findings from the ultraviolet study was limited, but the picrosirius red-polarized light procedure was found to be useful for estimating the age of the repair process as polarization colors of greater wavelengths progressively increased with the age of the lesion

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