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A Large Congenital Blue Plaque With Papules and Nodules on the Lower Back

Rubin, Courtney B. BS*; Boni, Andrea MD†; Elenitsas, Rosalie MD†; Pogoriler, Jennifer MD, PhD‡; Low, David MD§; Rubin, Adam I. MD†

American Journal of Dermatopathology: May 2017 - Volume 39 - Issue 5 - p 367–368
doi: 10.1097/DAD.0000000000000455
Clinical Pathologic Challenge

Departments of *Medical Ethics and Health Policy, and

†Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

‡Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and

§Department of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Reprints: Adam I. Rubin, MD, Department of Dermatology, Division of Dermatopathology, Hospital of the University of Pennsylvania, 2 Maloney Building, 3600 Spruce St, Philadelphia, PA 19104 (e-mail: adam.rubin@uphs.upenn.edu).

The authors declare no conflicts of interest.

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CLINICAL FINDINGS

A 9-year-old boy presented for evaluation of a pigmented lesion located on his lower back, over the spine. The lesion had been present since birth and had been growing proportionally with the patient. Physical examination revealed a blue plaque measuring 4 × 16 cm. Multiple small papules and nodules measuring 3–4 mm were noted within the larger plaque (Fig. 1). A magnetic resonance imaging of the back and spine showed no underlying abnormalities. A biopsy taken 7 years before from a nodular area showed histologic features consistent with cellular blue nevus. On request of the patient, a staged excision for complete removal was performed.

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HISTOPATHOLOGICAL FINDINGS

The sections showed diffuse dermal infiltration by elongated dendritic melanocytes scattered throughout the dermis, which extended into the subcutis and fascia. Some areas had cellular nodules composed of spindle and epithelioid cells reminiscent of a cellular blue nevus. Perivascular, perineural, and periadnexal extension of lesional melanocytes were present. The epidermis was unaffected. The histologically noted cellular nodules correlated clinically to the papules and nodules seen in the larger background plaque. There were no lesional mitoses, necrosis, or cytologic atypia (Fig. 2).

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WHAT IS YOUR DIAGNOSIS?

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