Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Spicknall, Kerith E MD; Mutasim, Diya F MD
Department of Dermatology, University of Cincinnati, Cincinnati, OH.
To the Editors:
Several malignant neoplasms have been reported to arise within epidermoid cysts. These include basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma,1 and mycosis fungoides.2
We report an epidermoid cyst with features of vacuolar interface dermatitis and lichenoid keratosis. The lesion was a 2-cm smooth, mobile nodule on the upper back of a 54-year-old white male. Microscopic examination showed a cystic structure lined by atrophic squamous epithelium and containing keratin. The wall of the cyst showed a band-like lymphocytic infiltrate in close approximation to the basement membrane with focal vacuolization of the basal layer, mimicking both a vacuolar interface dermatitis and benign lichenoid keratosis (Figs. 1 and 2). There was no evidence of cyst rupture, granulomatous inflammation, or keratinocyte atypia.
Although there is one report of lichen planus occurring in the lining of an epidermoid cyst in a patient with extensive lichen planus,3 our patient had no lesions elsewhere to suggest lichen planus or a lichenoid interface dermatitis. Thus, the pathogenesis of the findings of vacuolar interface dermatitis and lichenoid keratosis in our patient's cyst is unclear, but our report adds to the literature another histopathologic finding that may be seen within epidermoid cysts.
Kerith E. Spicknall, MD
Diya F. Mutasim, MD
Department of Dermatology, University of Cincinnati, Cincinnati, OH
© 2010 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at The American Journal of Dermatopathology.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics