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American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3181c20f34
Letter to the Editor

Review of and Comments on Article “Viral-Associated Nonmelanoma Skin Cancers: A Review”

Rodriguez, Gerzain MD

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School of Medicine, Universidad de La Sabana, Chía, Colombia.

To the Editor:

In the review of Dubina and Goldenberg,1 the legend for figure 1B says: “Keratinocytes show typical perinuclear halos and blue-gray pallor.” Not a single perinuclear halo is seen in the figure. Instead, what is clearly apparent is the clear, “vacuolar” appearance of nuclei of the upper malpighian layer and in the granular layer. The nuclei also show a peripheral rim of condensed chromatin. This is the typical image of flat warts of epidermodysplasia verruciformis (EV) and a clue to differentiate it from other flat warts. This image is particularly apparent in half-micron sections stained with toluidine blue (Fig. 1), and by electron microscopy correspond to fine granular material at the periphery of which viral crystals are formed (Fig. 2).

Figure 1
Figure 1
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Figure 2
Figure 2
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Gerzain Rodriguez, MD

School of Medicine, Universidad de La Sabana, Chía, Colombia

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REFERENCE

1. Dubina M, Goldenberg G. Viral-associated nonmelanoma skin cancers: a review. Am J Dermatopathol. 2009;31:561-573.

© 2010 Lippincott Williams & Wilkins, Inc.

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