Nail Matrix Pathology in Cronkhite-Canada Syndrome: The First Case Report.Chuamanochan, Mati MD; Tovanabutra, Napatra MD; Mahanupab, Pongsak MD; Kongkarnka, Sarawut MD; Chiewchanvit, Siri MDAmerican Journal of Dermatopathology: Post Author Corrections: April 03, 2017 doi: 10.1097/DAD.0000000000000898 Extraordinary Case Report: PDF Only Abstract Cronkhite-Canada Syndrome (CCS) presents with gastrointestinal polyposis and the triad of cutaneous abnormalities including nail dystrophy, alopecia, and hyperpigmentation of the skin. The etiology is not well understood. The histology of skin lesion in CCS has not been routinely described. Especially, the nail matrix pathology has not been reported. In this study, the authors report the nail matrix pathology in a patient with CCS. Interestingly, the histologic evaluation revealed matrix hypergranulosis. Because matrix hypergranulosis is commonly found in several inflammatory nail diseases, this discovery points out that an inflammatory process is probably one of the important pathogeneses in CCS. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
