Role of Skin Biopsies in the Diagnosis of Hemophagocytic LymphohistiocytosisSantos-Arroyo, Aileen MD*; Barrera-Llaurador, Julián MD†; Sánchez, Julio E. MD*; Martín-García, Rafael MD*; Sánchez, Jorge L. MD*American Journal of Dermatopathology: July 2017 - Volume 39 - Issue 7 - p e86–e89 doi: 10.1097/DAD.0000000000000825 Extraordinary Case Report Abstract Author Information Abstract: This is a report of a 15-year-old female who presented with a skin eruption and clinical features consistent with severe sepsis and septic shock. A diagnosis of acquired hemophagocytic lymphohistiocytosis (HLH) was made and confirmed by bone marrow analysis. Skin biopsy showed hemophagocytosis and CD163-positive staining of macrophages. We briefly review the clinical, histologic, and laboratory findings of hemophagocytic lymphohistiocytosis in addition to the potential role of skin biopsies in this condition. *Department of Dermatology, University of Puerto Rico—School of Medicine, San Juan, Puerto Rico; and †Transitional Year Program, University of Puerto Rico—School of Medicine, San Juan, Puerto Rico. Reprints: Julián Barrera-Llaurador, MD, Department of Dermatology, University of Puerto Rico Medical Science Campus, PO Box 365067, San Juan, PR 00936-5067 (e-mail: julian.barrera@upr.edu). The authors declare no conflict of interests. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
