Abstract: Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma.
*Institute of Pathology, Rabin Medical Center—Beilinson Hospital, Petach Tikva, Israel;
†Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
‡Department of Oncology, Soroka Medical Center, Beer Sheva, Israel;
§Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel;
¶Institute of Pathology, Soroka Medical Center, Beer Sheva, Israel; and
‖Department of Cardiothoracic Surgery, Rabin Medical Center—Beilinson Hospital, Petach Tikva, Israel.
Reprints: Yulia Shvartser-Beryozkin, MD, Institute of Pathology, Rabin Medical Center—Beilinson Hospital, Petach Tikva 4941492, Israel (e-mail: yuliashv@clalit.org.il).
The authors declare no conflicts of interest.
