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Linear Folliculotropic CD30-Positive Lymphomatoid Drug Reaction

Chen, Yi-Chin MD*; Wu, Yu-Hung MD*,†

American Journal of Dermatopathology: May 2017 - Volume 39 - Issue 5 - p e62–e65
doi: 10.1097/DAD.0000000000000795
Extraordinary Case Report

Abstract: We report a unique case of probable drug-induced CD30-positive lymphomatoid reaction. A 58-year-old woman presented with bilateral facial eruptions of 3 weeks duration composed of erythematosus papules in a linear distribution. The pathological features demonstrated a dense dermal and follicular infiltrate of many medium- to large-sized atypical CD30-positive lymphoid cells. The rash resolved rapidly after discontinuation of her medication 1 week later and did not recur. This case highlights the importance of clinicopathological correlation.

*Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan; and

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Reprints: Yu-Hung Wu, MD, Department of Dermatology, Mackay Memorial Hospital, No. 92, Section 2, Zhongshan N. Road, Taipei, Taiwan 10449 (e-mail: yuhung_wu@yahoo.com).

The authors declare no conflicts of interest.

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