Skip Navigation LinksHome > August 2014 - Volume 36 - Issue 8 > Histological Spectrum of Cutaneous Herpes Infections
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American Journal of Dermatopathology:
doi: 10.1097/DAD.0000000000000148
CME Article

Histological Spectrum of Cutaneous Herpes Infections

Hoyt, Brian BS*; Bhawan, Jag MD

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Abstract

Herpes simplex virus and varicella zoster virus are double-stranded DNA viruses that commonly infect humans, resulting in cutaneous manifestations. Diagnosis is generally made based on clinical findings; however, when the presentation is atypical, biopsy can aid in making a correct diagnosis. The classic histopathological findings of herpetic infection are well established (acantholysis, ballooning degeneration, intranuclear inclusions, multinucleation, necrosis, and formation of vesicles or ulcers). Herpes infection can also cause histopathological changes in many dermal structures. Furthermore, herpes can masquerade as a variety of hematologic malignancies or benign cutaneous conditions. The histopathological spectrum of herpes infections is reviewed and discussed.

© 2014 Lippincott Williams & Wilkins

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