Skip Navigation LinksHome > May 2014 - Volume 36 - Issue 5 > Negative Pigment Network and Shiny White Streaks: A Dermosco...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0000000000000019
Brief Report

Negative Pigment Network and Shiny White Streaks: A Dermoscopic–Pathological Correlation Study

Pizzichetta, Maria A. MD*; Canzonieri, Vincenzo MD; Soyer, Peter H. MD, FACD; Rubegni, Pietro MD§; Talamini, Renato ScD*; Massone, Cesare MD

Collapse Box

Abstract

It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic–histopathologic correlation of NPN and SWS, we have performed a dermoscopic–pathological correlation study. A total of 25 skin lesions dermoscopically characterized by the presence of NPN and/or SWS, including histopathologically confirmed dermatofibroma (2), Spitz nevus (3), compound nevus (6), dysplastic nevus (7), and melanoma (7), were evaluated for the presence of NPN, SWS, and blue-white veil. The histopathologic features such as orthokeratosis, orthokeratosis plus nests of pigmented melanocytes at the junction, hypergranulosis, hypergranulosis plus nests of pigmented melanocytes at the junction, epidermal invagination plus orthokeratosis, fibrosis, lamellar fibrosis, and elongation and bridging of rete ridges were evaluated. We found a disagreement in 80% of skin lesions between NPN and fibrosis (P = 0.02). For SWS, a significant agreement emerged with hypergranulosis (76%; P = 0.01), and the same occurred with fibrosis (80%; P = 0.01). Moreover, blue-white veil also displayed a significant agreement with hypergranulosis (68%; P = 0.04). Our findings confirm the correlation of SWS with fibrosis, whereas a clear-cut histopathologic substrate of NPN could not be established.

© 2014 Lippincott Williams & Wilkins

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.