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Asynchronous Presentation of Follicle Center Lymphoma and Reactive Lymphoid Hyperplasia of the Ocular Adnexa

Sahu, Joya MD*; Lee, Junhee MD; Lee, Michael D. MD*; Gummadi, Sriharsha BS; Lee, Jason B. MD*

American Journal of Dermatopathology: April 2014 - Volume 36 - Issue 4 - p e87–e92
doi: 10.1097/DAD.0b013e3182a36541
Extraordinary Case Report

Abstract: Although ocular lymphoproliferative diseases may be rarely encountered by dermatopathologists, the frequency may increase particularly as more and more subspecialties rely on dermatopathology services. Emerging data suggest that there are some similarities between ocular and cutaneous lymphoproliferative diseases with respect to their clinical behavior, prognosis, and cytogenetics. In this case report, a patient with ocular follicle center lymphoma who subsequently developed ocular reactive lymphoid hyperplasia is presented with an accompanying review of the literature on the subjects. The encounter of both follicular center lymphoma and reactive lymphoid hyperplasia in the same patient provides a rare opportunity to compare and contrast the clinical, histological, and immunohistochemical findings of the respective lymphoproliferative diseases situated at opposite ends of the spectrum.

*Department of Dermatology and Cutaneous Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA;

Center for Excellence in Eye Care, Miami, FL; and

Jefferson Medical College, Philadelphia, PA.

Reprints: Jason B. Lee, MD, Department of Dermatology and Cutaneous Biology, Jefferson Medical College of Thomas Jefferson University, 833 Chestnut Suite 704, Philadelphia, PA 19107 (e-mail: Jason.lee@jefferson.edu).

The authors declare no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins.