Skip Navigation LinksHome > March 2014 - Volume 36 - Issue 3 > Trichodysplasia Spinulosa Associated With Lupus
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e318293f620
Extraordinary Case Report

Trichodysplasia Spinulosa Associated With Lupus

Moktefi, Anissa MD*; Laude, Hélène MD, PhD†,‡; Brudy Gulphe, Laurence MD§; Rozenberg, Flore MD, PhD†,‡; Vacher Lavenu, Marie Cécile MD, PhD*; Dupin, Nicolas MD‡,§; Carlotti, Agnès MD*

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Abstract

Trichodysplasia spinulosa (TS) is a unique clinical and histological entity described in immunosuppressed patients. The recent discovery of genomic DNA from a new Polyomavirus named trichodysplasia spinulosa–associated Polyomavirus in TS lesions and good clinical response to cidofovir strengthens the hypothesis of a viral etiology for the disease. The authors report a case of TS associated with lupus erythematosus in a 26-year-old woman with no history of transplant, hemopathy, or cyclosporine treatment. The patient developed a progressive worsening eruption composed of confluent papules and spiky filiform excrescences concentrated in the midfacial area. Pathological features were characterized by aberrant distended and abnormally maturated hair follicles with sheets of eosinophilic cells containing large purple granules, and the presence of trichodysplasia spinulosa–associated Polyomavirus DNA was confirmed by polymerase chain reaction. This case is the first description in a nontransplanted lupus patient without underlying hemopathy.

© 2013 Lippincott Williams & Wilkins

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