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Giant Keratoacanthoma: Case Report and Review of the English Literature

Bogner, Paul N. MD*; Cheney, Richard T. MD*; Zeitouni, Nathalie C. MDCM, FRCPC

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e318291c582
Brief Report

Abstract: The giant keratoacanthoma (KA) is a rare variant of KA with a maximum size exceeding 2–3 cm. Like other forms of KA, it has a tendency to spontaneously regress but can cause significant anatomic damage. A 69-year-old male presented to our hospital with a giant KA of the nose that showed complete pathological regression by the time of surgery. Pathology showed dermal scar with keratin granulomas extending through the nasal wall to the respiratory mucosa. A total of 57 similar cases from the English literature were reviewed for comparison. Few provide similar details of histological regression. Literature cases occurred predominately in males (74.1%) with a mean age of 59 years. Head tumors were most common (70.7%) and most were treated by surgery (34.5%) or a combination of surgery and radiotherapy (24.1%). Other treatment modalities reported include methotrexate, 5-fluorouracil, and interferon.

Author Information

*Departments of Pathology, and

Dermatology, Roswell Park Cancer Institute, Buffalo, NY.

Reprints: Paul N. Bogner, MD, Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14263 (e-mail:

The authors declare no conflicts of interest and source of funding.

The authors have indicated no significant interest with commercial supporters.

© 2014 by Lippincott Williams & Wilkins.