Skip Navigation LinksHome > March 2014 - Volume 36 - Issue 3 > Biclonal Chronic Lymphocytic Leukemia Presenting as Skin Les...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3182a3326d
Brief Report

Biclonal Chronic Lymphocytic Leukemia Presenting as Skin Lesion

Singh, Anurag MD*; Graziano, Stephen MD*; Vajpayee, Neerja MD

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Abstract

Chronic lymphocytic leukemia (CLL) is by far the most common mature B-cell leukemia in Western countries. Some patients with CLL present with manifestations of extra medullary disease. We report a case of biclonal CLL/small lymphocytic lymphoma in an elderly patient who initially presented with skin lesions, no other systemic symptoms, and normal white cell count. Skin biopsy revealed concurrence of basal cell carcinoma and a nodular dermal infiltrate with immunophenotype consistent with CLL/small lymphocytic lymphoma. Polymerase chain reaction assay for immunoglobulin heavy chain gene rearrangement revealed the presence of 2 distinct B-cell clones in the peripheral blood. The clinicopathological characterization of this case is presented here.

© 2014 Lippincott Williams & Wilkins

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