Skip Navigation LinksHome > March 2014 - Volume 36 - Issue 3 > Angiomatous Kaposi Sarcoma: A Variant That Mimics Hemangioma...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3182996ccd
Original Study

Angiomatous Kaposi Sarcoma: A Variant That Mimics Hemangiomas

Yang, Sara H. MD*; LeBoit, Philip E. MD*,†,‡,§

Collapse Box

Abstract

We describe 14 cases of angiomatous Kaposi sarcoma (KS), a distinct histological variant of KS first mentioned by Gottlieb and Ackerman in 1988 that can easily be mistaken for a hemangioma. Intriguingly, this variant of KS has not attracted much attention and has not been studied in detail. Immunohistochemistry showed prominent staining of podoplanin (D2-40) of the neoplastic vasculature but not the preexisting vessels, suggesting lymphatic differentiation, despite the erythrocyte-filled round lumens. To test whether D2-40 staining of round vessels with erythrocytes was distinctive, we stained sinusoidal hemangiomas and cellular angiolipomas, both of which have these structures. In contrast to angiomatous KS, the vessels in both entities were podoplanin (D2-40) negative. The finding of round erythrocyte-filled vessels with podoplanin (D2-40) positivity may be distinctive for this form of KS.

© 2013 Lippincott Williams & Wilkins

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.