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Angioinvasive Lymphomatoid Papulosis: Another Case of a Newly Described Variant

Sharaf, Mohammed A. MD; Romanelli, Paolo MD; Kirsner, Robert MD, PhD; Miteva, Mariya MD

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3182943394
Extraordinary Case Report
Abstract

Abstract: Lymphomatoid papulosis (LyP) is a chronic recurrent lymphoproliferative disorder characterized clinically by self-regressing cutaneous lesions. Histologically, it is recognized by clusters of CD30+ atypical lymphocytes in the background of mixed inflammatory infiltrate. It has been classified as type A, B, C, and D. Recently, a further variant of LyP was described as “angioinvasive LyP” in a series of 16 patients. We report a case of a 73-year-old female presenting with papules and nodules on the extremities evolving into eschar-like necrotic plaques. Histological examination revealed medium- to large-sized atypical lymphoid CD30+ cells densely infiltrating the dermis with distinct angioinvasion and angiodestruction. No systemic involvement was identified. The clinicopathologic features conformed to the newly described angioinvasive LyP.

Author Information

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL.

Reprints: Mohammed A. Sharaf, MD, Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, RSMB, Room 2023A, Miami, FL 33136 (e-mail: dr.mohammedsharaf@gmail.com).

The authors declare no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins.