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American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3182943394
Extraordinary Case Report

Angioinvasive Lymphomatoid Papulosis: Another Case of a Newly Described Variant

Sharaf, Mohammed A. MD; Romanelli, Paolo MD; Kirsner, Robert MD, PhD; Miteva, Mariya MD

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Abstract

Lymphomatoid papulosis (LyP) is a chronic recurrent lymphoproliferative disorder characterized clinically by self-regressing cutaneous lesions. Histologically, it is recognized by clusters of CD30+ atypical lymphocytes in the background of mixed inflammatory infiltrate. It has been classified as type A, B, C, and D. Recently, a further variant of LyP was described as “angioinvasive LyP” in a series of 16 patients. We report a case of a 73-year-old female presenting with papules and nodules on the extremities evolving into eschar-like necrotic plaques. Histological examination revealed medium- to large-sized atypical lymphoid CD30+ cells densely infiltrating the dermis with distinct angioinvasion and angiodestruction. No systemic involvement was identified. The clinicopathologic features conformed to the newly described angioinvasive LyP.

© 2013 Lippincott Williams & Wilkins

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