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Pitfalls in the Diagnosis of Cutaneous Lymphoma

Batrani, Meenakshi MD; Bhawan, Jag MD

The American Journal of Dermatopathology: January 2014 - Volume 36 - Issue 1 - p 90–100
doi: 10.1097/DAD.0b013e31827654cd
Review Article

Abstract: Cutaneous lymphomas are primarily classified as cutaneous T-cell/natural killer (NK) cell lymphomas and B-cell lymphomas; their classification being of utmost importance for prognostic and therapeutic purposes. Despite certain distinguishing attributes related to both these categories of lymphomas, considerable overlaps and deviations from the usual features exist and can lead to misclassification. The objective of this review is to discuss the various pitfalls involving morphology, immunohistochemistry, and gene rearrangement studies, all of which pose challenges in classifying cutaneous lymphomas as either the T-cell/natural killer cell or B-cell type.

Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, Boston, MA.

Reprints: Jag Bhawan, MD, Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118 (e-mail: jbhawan@bu.edu).

Disclosures: The authors no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins.