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Mantle Cell Lymphoma of Blastoid Variant With Skin Lesion and Rapid Progression: A Case Report and Literature Review

Cao, Qinghua MD; Li, Yang MD, PhD; Lin, Hanliang MD; Ke, Zunfu PhD; Liu, Yongdong MD; Ye, Ziyin MD

American Journal of Dermatopathology: December 2013 - Volume 35 - Issue 8 - p 851–855
doi: 10.1097/DAD.0b013e31828de73a
Brief Report

Abstract: Mantle cell lymphoma (MCL) is a type of aggressive mature B-cell neoplasm. Skin involvement of MCL is extremely rare, with only 21 cases reported so far. We report a case of MCL with blastoid variant, presenting as skin lesion initially. A 53-year-old man presented with increasing petechiae and ecchymosis after slight hit. Biopsy of skin showed tumor cells densely infiltrated dermal and subcutis with blastoid cytological features and numerous mitotic figures. Immunohistochemistry study showed tumor cells were positive for CD20, CD79a, BCL2, CyclinD1, and MUM1 but lost CD5 expression. Fluorescence in situ hybridization (FISH) studies demonstrated t(11;14). Although received chemotherapy after the diagnosis established, the patient deteriorated rapidly and died 5 weeks after presenting with skin lesions.

Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Reprints: Ziyin Ye, MD, Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, 58#, Zhongshan Rd II, Guangzhou 510080, China (e-mail: yeziyin@mail.sysu.edu.cn).

Q. Cao and Y. Li have contributed equally to the manuscript. They are the first coauthors.

The authors declare no conflicts of interest.

© 2013 by Lippincott Williams & Wilkins.