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Pseudotumoral Cutaneous Aspergillosis in Chronic Granulomatous Disease, Report of a Pediatric Case

Khemiri, Monia MD*; El fekih, Nadia MD; Borgi, Aida MD*; Kharfi, Monia MD; Boubaker, Samir MD; Barsaoui, Sihem MD*

American Journal of Dermatopathology: October 2012 - Volume 34 - Issue 7 - p 749–752
doi: 10.1097/DAD.0b013e3182562451
Brief Report

Abstract: Invasive aspergillosis is a life-threatening condition in patients with chronic granulomatous disease (CGD). Skin invasion by Aspergillus occurs most commonly by contiguity to a neighboring cavity. We describe an unusual case of invasive cutaneous aspergillosis presented as a large burgeoning tumor in a 4-year-old girl with CGD who underwent surgical treatment for bifocal osteomyelitis of the left leg. The skin invasion occurred 4 months after a “successful” treatment of invasive pulmonary aspergillosis. Atypical presentation and diagnostic difficulties are discussed. Invasive cutaneous aspergillosis may be polymorphic. The diagnosis should be considered early in the etiological investigation of any suspicious skin lesions in CGD even in uncommon aspects such as burgeoning tumors.

*Pediatric A Department, Children's Hospital of Tunis, Faculty of Medicine, University of Tunis El manar, Tunisia

Department of Dermatology, Charles Nicolle's Hospital, Faculty of Medicine, University of Tunis El manar, Tunisia

Department of Pathology, Institut Pasteur, Faculty of Medicine, University of Tunis El Manar, Tunisia.

Reprints: Monia Khemiri, MD, Pediatric A Department, Children's Hospital of Tunis Bab Saadoun-Jabbary PC: Faculty of Medicine University of Tunis El Manar, Tunis 1007, Tunisia (e-mail: monia.khemiri@rns.tn).

The authors declare no conflicts of interest.

© 2012 Lippincott Williams & Wilkins, Inc.