You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Cutaneous Reactions to Novel Therapeutics

Hoang, Mai P. MD*; Kroshinsky, Daniela MD

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31822e67eb
CME Article

Abstract: In the last 2 decades the introduction new biologic agents such as tumor necrosis factor alpha inhibitors has resulted in potent disease modifying effects in a variety of immune-mediated diseases. In addition, there were major advancements in cancer treatment due to chemotherapeutic agents including granulocyte macrophage-colony-stimulating factor, interferon, epidermal growth factor receptor inhibitors, and kinase inhibitors for the treatment of hematologic malignancies as well as solid tumors. However, a variety of toxicities including cutaneous reactions is seen in association with these agents. Awareness of commonly associated skin toxicities and recognition of corresponding histologic features is of importance.

Author Information

*Associate Professor of Pathology

Assistant Professor of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.

All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Reprints: Mai P. Hoang, MD, Dermatopathology Unit, Massachusetts General Hospital, 55 Fruit Street, Warren 820, Boston, MA 02114 (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.