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Reactivation of Chagas Disease by Immunosuppressive Therapy in a Patient With Systemic Lupus Erythematosus: Report of an Exceptional Case

Burgos, Lourdes Gonzalez MD*; Ortiz, Beatriz Di Martino MD*; Canese, Andrés MD; Ojeda, Aldo MD; Melo, Marcia MD

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e318257f9e2
Extraordinary Case Report

Abstract: Chagas disease is a zoonosis caused by the protozoan Trypanosoma cruzi. It presents as a chronic evolution and produces high morbidity and mortality in countries where the disease is endemic, as in ours. The skin disease is very rare and results from the reactivation of latent disease as a result of immunosuppression, presenting with acute, atypical, and severe lesions. We describe the case of a patient who was unaware of being a carrier of Chagas disease and presented reactivation after immunosuppressive therapy instituted to treat her systemic lupus erythematosus.

Author Information

*Department of Dermatology

Department of Medical Microbiology and Parasitology

Department of Rheumatology, Clínicas Hospital, Faculty of Medical Sciences, National University of Asuncion, Paraguay.

Reprints: Beatriz Maria Di Martino Ortiz, MD, 1033 Paraguarí Street, Asuncion1325, Paraguay (e-mail:

The authors declare no conflict of interest.

© 2012 Lippincott Williams & Wilkins, Inc.