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American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31821e8744
CME Article

Matrix Metalloproteinases in Health and Disease: Insights From Dermatopathology

Hernández-Pérez, Marier MD*; Mahalingam, Meera MD, PhD, FRCPath

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Abstract

Abstract: Matrix metalloproteinases, a group of over 26 zinc-dependent enzymes, share a similar structure to each other and functionally are capable of degrading almost every component of the extracellular matrix. They are essential to normal development during embryogenesis and extracellular matrix remodeling and, given this, understandably enough have been implicated in multiple pathologic processes that encompass the inflammatory and neoplastic spectrum of disease. This review attempts to define roles of matrix metalloproteinases of relevance in normal skin and to elucidate their roles in inflammatory dermatoses and benign and malignant neoplasms.

© 2012 Lippincott Williams & Wilkins, Inc.

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