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Matrix Metalloproteinases in Health and Disease: Insights From Dermatopathology

Hernández-Pérez, Marier MD*; Mahalingam, Meera MD, PhD, FRCPath

The American Journal of Dermatopathology: August 2012 - Volume 34 - Issue 6 - p 565–579
doi: 10.1097/DAD.0b013e31821e8744
CME Article

Abstract: Matrix metalloproteinases, a group of over 26 zinc-dependent enzymes, share a similar structure to each other and functionally are capable of degrading almost every component of the extracellular matrix. They are essential to normal development during embryogenesis and extracellular matrix remodeling and, given this, understandably enough have been implicated in multiple pathologic processes that encompass the inflammatory and neoplastic spectrum of disease. This review attempts to define roles of matrix metalloproteinases of relevance in normal skin and to elucidate their roles in inflammatory dermatoses and benign and malignant neoplasms.

*Pathology Resident, Department of Pathology and Laboratory Medicine

Professor of Dermatology and Pathology and Laboratory Medicine, Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, Boston, MA.

The authors and all staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Reprints: Meera Mahalingam, MD, PhD, FRCPath, Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, 609 Albany Street, J-301, Boston, MA 02118 (e-mail: mmahalin@bu.edu).

© 2012 Lippincott Williams & Wilkins, Inc.