Lymph Node Melanosis From a Primary Cutaneous Lesion Combining a Nodular (Tumoral) Melanosis and a Congenital Dermal Melanocytic NevusRongioletti, Franco MD*,†; Pavesi, Alessandra MD*; Carli, Carla MD†; Parodi, Aurora MD*; Fiocca, Roberto MD†The American Journal of Dermatopathology: August 2012 - Volume 34 - Issue 6 - p 653–657 doi: 10.1097/DAD.0b013e3182447f73 Extraordinary Case Report Abstract Author Information Abstract: Tumoral or nodular melanosis is considered as a rare manifestation of a completely regressed melanoma whose histopathological features include confluent dermal nodular aggregates of heavily melanized polygonal cells consistent with melanophages. Tumoral melanosis involving also lymph node is an even rarer event that has been reported only twice in the literature. We report a case of lymph node melanosis in the sentinel lymph node draining from a primary cutaneous lesion combining a dermal tumoral melanosis consistent with a complete regressed melanoma associated with a residual part of a deep congenital nevus. We discuss the histopathological diagnosis of our primary cutaneous lesion and the sentinel lymph node microscopic findings, compare our case with the previous ones, and discuss the possible prognostic and therapeutic implications. *Section of Dermatology, DISSAL †Department of Anatomic Pathology, DISC, University of Genova, Genoa, Italy. Reprints: Franco Rongioletti, MD, Clinica Dermatologica, Università di Genova, viale Benedetto XV, 7, Genova, Italy (e-mail: firstname.lastname@example.org). The authors declare no conflicts of interest. © 2012 Lippincott Williams & Wilkins, Inc.