Skip Navigation LinksHome > August 2012 - Volume 34 - Issue 6 > Expression of CXCR4, E-Cadherin, Bcl-2, and Survivin in Merk...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31823e25d3
Original Study

Expression of CXCR4, E-Cadherin, Bcl-2, and Survivin in Merkel Cell Carcinoma: An Immunohistochemical Study Using a Tissue Microarray

Knapp, Charles F. MD*; Sayegh, Zena MD; Schell, Michael J. PhD; Rawal, Bhupendra MS; Ochoa, Tatiana MD; Sondak, Vernon K. MD; Messina, Jane L. MD

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Abstract: Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous malignancy with a mortality rate exceeding that of melanoma. Although smaller studies of markers of progression have been performed, large-scale investigation has been difficult due to the rarity of this tumor. Investigation of 4 potential immunohistochemical progression markers using an MCC tissue microarray was performed. An immunohistochemical analysis of CXCR4, E-cadherin, Bcl-2, and Survivin was performed on a tissue microarray of two hundred twenty-seven 0.6-mm tumor cores—110 primary, 73 local/regional metastatic, and 44 distant metastatic—from 87 patients, 23 of which were sampled 2 or more times. There was a statistically significant increase in immunoreactivity to CXCR4 and Survivin in local/regional nodal MCC metastases compared with primary and distant metastatic lesions. No significant differences by disease location were found for either Bcl-2 or E-cadherin. These results suggest a potential role for CXCR4 and Survivin in MCC tumor progression. However, previous data from other studies suggesting a role for Bcl-2 and E-cadherin in MCC progression are not confirmed in this larger sample. Further discovery of additional markers are needed to better characterize this rare but deadly malignancy.

© 2012 Lippincott Williams & Wilkins, Inc.


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