Skip Navigation LinksHome > August 2012 - Volume 34 - Issue 6 > Cowden Syndrome: Report of Two Cases With Immunohistochemic...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31824a22f9
Brief Report

Cowden Syndrome: Report of Two Cases With Immunohistochemical Analysis for PTEN Expression

Zabetian, Saba BS*; Mehregan, Darius MD

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Abstract: Cowden syndrome (CS) is a rare autosomal dominant disorder characterized by multisystem hamartomatous growths and carcinomas. CS is linked to germ line mutations in PTEN (phosphatase and tensin homolog) located on chromosome 10q23.3. PTEN acts as a tumor suppressor to negatively control cellular growth and survival via the PI3K/AKT signaling pathway. Presented here are 2 patients with multiple, persistent, and asymptomatic papules on the face and the upper body, histologically consistent with trichilemmomas. Diagnosis of CS was made in each case based on the established diagnostic criteria and confirmed using immunohistochemistry directed against PTEN. We propose that the assessment of PTEN expression levels can aid in the identification of patients with CS.

© 2012 Lippincott Williams & Wilkins, Inc.


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