Background: Cutaneous arteriovenous malformations (AVMs) of stage I may mimic port-wine stains (PWSs) clinicopathologically; therefore, it may be misdiagnosed and mistreated as being PWS.
Objective: To suggest the clinicopathological differential clues between early AVMs and PWSs.
Methods: A set of 10 radiologically proven AVMs of stage I was selected in conjunction with a set of 10 age-/sex-matched PWSs as a control. Their clinical features, hematoxylin and eosin, CD31, and smooth muscle actin immunohistochemistry were then compared.
Results: Four pathological clues for differential diagnosis with statistical significance (P < 0.05) were found: the vessel density (CD31), presence of vascular luminal red blood cells, elongation and haphazard branching of vessels, and thickened vessel walls highlighted by smooth muscle actin.
Conclusion: Therefore, 4 differential clues with respect to stage I AVM and PWS in their earlier developmental stages have been proposed.
*Department of Dermatology
†Vascular Anomaly Clinic
‡Department of Pathology, Kyungpook National University School of Medicine, Daegu, South Korea.
Supported by Industry-Academic Cooperation Foundation, Kyungpook National University (2008).
Conflicts of interest: None identified.
Reprints: Seok-Jong Lee, MD, Department of Dermatology, Kyungpook National University Hospital, 50 Samduk 2-ga Jung-Gu, Daegu, South Korea 700-721 (e-mail: email@example.com).