Skip Navigation LinksHome > July 2012 - Volume 34 - Issue 5 > Capillary Malformation of Port-Wine Stain: Differentiation...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3181b76443
Clinicopathologic Correlation

Capillary Malformation of Port-Wine Stain: Differentiation From Early Arteriovenous Malformation by Histopathological Clues

Lee, Seok-Jong MD*,†; Kim, Ho Youn MD*; Kim, Byung Soo MD*; Kim, Do Won MD*; Chung, Ho Yun MD; Lee, Jong Min MD; Huh, Seung MD; Bae, Han Ik MD

Collapse Box

Abstract

Background: Cutaneous arteriovenous malformations (AVMs) of stage I may mimic port-wine stains (PWSs) clinicopathologically; therefore, it may be misdiagnosed and mistreated as being PWS.

Objective: To suggest the clinicopathological differential clues between early AVMs and PWSs.

Methods: A set of 10 radiologically proven AVMs of stage I was selected in conjunction with a set of 10 age-/sex-matched PWSs as a control. Their clinical features, hematoxylin and eosin, CD31, and smooth muscle actin immunohistochemistry were then compared.

Results: Four pathological clues for differential diagnosis with statistical significance (P < 0.05) were found: the vessel density (CD31), presence of vascular luminal red blood cells, elongation and haphazard branching of vessels, and thickened vessel walls highlighted by smooth muscle actin.

Conclusion: Therefore, 4 differential clues with respect to stage I AVM and PWS in their earlier developmental stages have been proposed.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.