You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Considerations on the Performance of Immunohistochemistry for Mismatch Repair Gene Proteins in Cases of Sebaceous Neoplasms and Keratoacanthomas With Reference to MuirTorre Syndrome

Fernandez-Flores, Angel MD, PhD

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3182226a28
Review Article
Abstract

Abstract: Cutaneous sebaceous tumors, as well as keratoacanthomas, are associated with Muir–Torre syndrome (MTS). Visceral neoplasias are a feature of this syndrome; thus, early detection using a cutaneous biopsy is very important in dermatopathology. A dermatopathologist can apply different techniques in such cases, including immunohistochemistry for several mismatch repair proteins or molecular studies for microsatellites instability. However, in a world where economic resources play an increasing role, how discriminative the dermatopathologist should be in investigating cutaneous lesions that may indicate MTS is not a trivial matter. Although previous reports have presented algorithms on MTS focusing on a multidisciplinary approach, our report emphasizes the role of the dermatopathologist and tries to answer several questions that could arise when facing a cutaneous tumor that may indicate MTS.

Author Information

Department of Anatomic Pathology, Hospital El Bierzo, Ponferrada, Spain.

The authors report no conflicts of interest to declare.

Reprints: Angel Fernandez-Flores, MD, PhD, Servicio de Anatomia Patológica, Hospital El Bierzo, C/ Médicos sin Fronteras 7, 24411, Fuentesnuevas, Leon, Spain (e-mail: gpyauflowerlion@terra.es).

© 2012 Lippincott Williams & Wilkins, Inc.