Skip Navigation LinksHome > May 2012 - Volume 34 - Issue 3 > Cutaneous Clear Cell Neoplasms: A Histopathological Reappra...
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American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3182106d28
CME Article

Cutaneous Clear Cell Neoplasms: A Histopathological Reappraisal

Biswas, Asok MD, FRCPath, DipRCPath; Mahalingam, Meera MD, PhD, FRCPath

Continued Medical Education
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Abstract: Cutaneous clear cell neoplasms represent a heterogenous group of several primary and metastatic tumors with diverse histogenesis. Tumors with widespread clear cell change can seem strikingly similar under the microscope resulting in diagnostic difficulties. Although most cases are idiopathic, intracytoplasmic accumulation, artifact of tissue processing, and degenerative phenomenon have been cited as possible causes of clear cell change. An awareness of the various entities demonstrating this attribute, judicious use of ancillary techniques, and knowledge of the clinical setting are crucial to the accurate diagnosis. This review details the histological features of clear cell neoplasms of the skin with particular emphasis on the discriminating features.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


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