Skip Navigation LinksHome > August 2011 - Volume 33 - Issue 6 > Hemangiopericytoma-Like Dermatofibroma With Mast Cells
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American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31821e1a47
Brief Report

Hemangiopericytoma-Like Dermatofibroma With Mast Cells

Aneiros-Fernandez, Jose MD*; Arias-Santiago, Salvador MD†; Espiñeira-Carmona, Maria Jose MD†; Caba-Molina, Mercedes MD*; Fernandez-Pugnaire, Maria Antonia MD†; O'Valle, Francisco MD, PhD*; del Moral, Raimundo Garcia MD, PhD*; Aneiros-Cachaza, Jose MD, PhD*

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We report an unusual case of hemangiopericytoma-like dermatofibroma in the right shoulder of an 82-year-old patient with a well-defined nodular growth located in the dermis. Microscopic study revealed a band of haphazardly arranged cells with a vascular component of gaping, simple, endothelial-lined vascular structures with intervening postcapillary venules and capillary-sized slit-like “staghorn” vascular channels filled with erythrocytes; abundant mast cells were also observed. The neoplasm cells were positive for CD68 and Factor XIIIA and negative for CD34. Few data have been published on the presence of abundant mast cells (tryptase and CD117 positive) in these neoplasm. The differential diagnosis of this entity should consider other spindle cell neoplasm, including hemangiopericytoma/solitary fibrous tumor, dermatofibrosarcoma protuberans, myopericytoma, angioleiomyoma, amelanotic melanoma, pecoma, and benign and malignant peripheral nerve tumors. We present an infrequent case of dermatofibroma with a vascular pattern resembling hemangiopericytoma and the presence of abundant mast cells, which may be responsible for this vascular component.

© 2011 Lippincott Williams & Wilkins, Inc.


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