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Cutaneous Precursor B-Cell Lymphoblastic Lymphoma in Association With EpsteinBarr Virus

Alhaji, Mohammad MD; Sadikot, Ruxana T MD, MRCP (UK)

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e318209f0fe
Extraordinary Case Report

Precursor B-cell lymphoblastic lymphoma (B-LBL) is a rare high-grade neoplasm of immature B cells. Most of the reported cases in the literature represent cutaneous involvement in an existing systemic precursor B-LBL or leukemia rather than primary cutaneous disease. We report a rare case of primary cutaneous precursor B-LBL in an elderly male patient who presented with swelling and ulceration of his leg. Biopsy of the skin lesion showed precursor B-LBL. Immunohistochemistry was positive for terminal deoxytransferase, CD20, CD10, CD79a, and in situ hybridization was positive for Epstein-Barr virus. To our knowledge, this is the first report that shows an association between primary cutaneous precursor B-LBL with Epstein-Barr viral infection.

Author Information

From the *Department of Veterans Affairs, Jesse Brown VA Hospital; and †Cook County Hospital; and ‡Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois, Chicago, IL.

Reprints: Ruxana T. Sadikot, MD, MRCP (UK), FCCP, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois, 840 South Wood Street, M/C 719, Chicago, IL 60612 (e-mail:

© 2011 Lippincott Williams & Wilkins, Inc.