Skip Navigation LinksHome > August 2011 - Volume 33 - Issue 6 > Cutaneous Precursor B-Cell Lymphoblastic Lymphoma in Associa...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e318209f0fe
Extraordinary Case Report

Cutaneous Precursor B-Cell Lymphoblastic Lymphoma in Association With Epstein–Barr Virus

Alhaji, Mohammad MD; Sadikot, Ruxana T MD, MRCP (UK)

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Precursor B-cell lymphoblastic lymphoma (B-LBL) is a rare high-grade neoplasm of immature B cells. Most of the reported cases in the literature represent cutaneous involvement in an existing systemic precursor B-LBL or leukemia rather than primary cutaneous disease. We report a rare case of primary cutaneous precursor B-LBL in an elderly male patient who presented with swelling and ulceration of his leg. Biopsy of the skin lesion showed precursor B-LBL. Immunohistochemistry was positive for terminal deoxytransferase, CD20, CD10, CD79a, and in situ hybridization was positive for Epstein-Barr virus. To our knowledge, this is the first report that shows an association between primary cutaneous precursor B-LBL with Epstein-Barr viral infection.

© 2011 Lippincott Williams & Wilkins, Inc.


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