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Cutaneous Neoplasms With Prominent Verocay BodyLike Structures: The So-called Rippled Pattern

Biswas, Asok MD, FRCPath, Dip RCPath*; Setia, Namrata MD†; Bhawan, Jag MD‡

American Journal of Dermatopathology: August 2011 - Volume 33 - Issue 6 - pp 539-550
doi: 10.1097/DAD.0b013e31820562cd
CME Article

A striking appearance resulting from alternating areas of epithelial cell cords and stroma seen in some cutaneous adnexal neoplasms has been referred to as the “rippled pattern.” Histologically, this pattern may be indistinguishable from Verocay bodies described in schwannomas. A number of common and clinically diverse cutaneous neoplasms can be linked by the presence of this unusual growth pattern. The heterogeneous group of tumors that have been known to demonstrate this feature includes those with epithelial, adnexal, fibrohistiocytic, mesenchymal, and melanocytic lineage. The objective of this review is to alert the dermatopathologist to the range of neoplasms, which can potentially show this attribute, so that a misdiagnosis can be avoided.

From the *Department of Pathology, Western General Hospital, Edinburgh, United Kingdom; †Department of Pathology, Baystate Medical Center/Western Campus of Tufts University, Springfield, MA; and ‡Dermatopathology section, Department of Dermatology, Boston University School of Medicine, Boston, MA.

All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Reprints: Jag Bhawan, MD, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, 609 Albany St, J-308 Boston, MA 02118 (e-mail: jbhawan@bu.edu).

© 2011 Lippincott Williams & Wilkins, Inc.