Pseudoepitheliomatous hyperplasia (PEH) is a benign condition, characterized by hyperplasia of the epidermis and adnexal epithelium, closely simulating squamous cell carcinoma. PEH may be present in a number of conditions characterized by prolonged inflammation and/or chronic infection, as well as in association with many cutaneous neoplasms. Herein, we review different inflammatory, infectious, and neoplastic skin diseases, in which florid epidermal hyperplasia is a prominent histopathologic feature, and introduce a systematic approach in the interpretation of PEH.
*Dermatopathology Fellow, †Associate Professor of Dermatology and Pathology, Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, New Haven, CT.
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All staff in a position to control the content of this CME activity have disclosed that they have no financial relationships with, or financial interests in, any commercial companies pertaining to this educational activity.
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Reprints: Rossitza Lazova, MD, Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, PO Box 208059, 15 York St, New Haven, CT 06520 (e-mail: firstname.lastname@example.org).