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Pseudoepitheliomatous Hyperplasia: A Review

Zayour, Maya MD; Lazova, Rossitza MD

The American Journal of Dermatopathology: April 2011 - Volume 33 - Issue 2 - p 112-126
doi: 10.1097/DAD.0b013e3181fcfb47
CME Article

Pseudoepitheliomatous hyperplasia (PEH) is a benign condition, characterized by hyperplasia of the epidermis and adnexal epithelium, closely simulating squamous cell carcinoma. PEH may be present in a number of conditions characterized by prolonged inflammation and/or chronic infection, as well as in association with many cutaneous neoplasms. Herein, we review different inflammatory, infectious, and neoplastic skin diseases, in which florid epidermal hyperplasia is a prominent histopathologic feature, and introduce a systematic approach in the interpretation of PEH.

*Dermatopathology Fellow, †Associate Professor of Dermatology and Pathology, Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, New Haven, CT.

Unless otherwise noted below, each faculty's and staff's spouse/life partner (if any) has nothing to disclose.

The authors have disclosed that they have no significant relationship with or financial interests in any commercial companies that pertain to this educational activity.

All staff in a position to control the content of this CME activity have disclosed that they have no financial relationships with, or financial interests in, any commercial companies pertaining to this educational activity.

There was no funding for this project.

Reprints: Rossitza Lazova, MD, Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, PO Box 208059, 15 York St, New Haven, CT 06520 (e-mail: rossitza.lazova@yale.edu).

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