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American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3181d88d2e
Extraordinary Case Report

Superficial Thrombophlebitis: A New Clinical Manifestation of the Immune Reconstitution Inflammatory Syndrome in a Patient With HIV Infection

Alcaraz, Inmaculada MD*; Revelles, Juan Maria MD*; Camacho, Diana MD*; Haro, Rosario MD*; Fernández-Aceñero, María Jesús MD†; Fernández-Guerrero, Manuel MD‡; Requena, Luis MD*

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Abstract

Skin manifestations of immune reconstitution inflammatory syndrome in response to highly active antiretroviral therapy may account for up to 50% of the clinical presentations in this syndrome. Viable or dying infective antigens, host antigens, tumoral antigens, and others may target immune reconstitution inflammatory syndrome, resulting in a wide spectrum of clinical manifestations. We describe a 26-year-old HIV-infected man who had started highly active antiretroviral therapy a few months earlier. He developed multiple linear nodules following the superficial veins in both legs. Histopathologic examination demonstrated a mostly septal panniculitis with features of superficial thrombophlebitis. We propose that superficial thrombophlebitis should be added to the list of clinical manifestations of this newly observed immune restoration disease.

© 2010 Lippincott Williams & Wilkins, Inc.

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