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Multiple Desmoplastic Cellular Neurothekeomas Localized to the Face of a 16-Year-Old Boy

García-Gutiérrez, Monica MD*; Toussaint-Caire, Sonia MD†; González-Sánchez, Pablo MD‡; Ortiz-Hidalgo, Carlos MD*§

American Journal of Dermatopathology: December 2010 - Volume 32 - Issue 8 - pp 841-845
doi: 10.1097/DAD.0b013e3181c98f89
Extraordinary Case Report

Cellular neurothekeomas are relative uncommon benign dermal tumors of uncertain histogenesis. Most commonly they arise as a solitary papule or nodule on the head and neck or upper trunk of young adults with a slight female predominance. There has been only 1 previous report of multiple neurothekeomas. The patient described herein was a 16-year-old otherwise healthy boy who presented with approximately 30 facial papules that arose over the course of 6 months and progressively enlarged. Histologically, all lesions were composed of spindled to epithelioid cells, but varied in the degree of cellularity and dermal sclerosis. Immunohistochemical staining showed that the cells of interest expressed S100A6, vimentin, CD63 (NKI/C3), PGP 9.5, and factor XIIIa and were negative for CD68, glial fibrillary acid protein (GFAP), S-100, HMB-45, epithelial membrane antigen, actin, and CD57 consistent with a diagnosis of multiple desmoplastic cellular neurothekeomas.

From the *Department of Pathology, American British Cowdray Medical Center, Mexico City, Mexico; †Department of Dermatology, Hospital General “Dr. Manuel Gea González”, SS, Mexico City, Mexico; ‡Department of Dermatology, Medica la Piedad, La Piedad, Michoacán, Mexico; and §Department of Tissue and Cell Biology, Universidad Panamericana, Mexico City, Mexico.

Reprints: Carlos Ortiz-Hidalgo MD, Department of Pathology, ABC Medical Center, Sur 136#116, Col Las Américas, Mexico DF 01120, Mexico (e-mail: cortiz@abchospital.com).

© 2010 Lippincott Williams & Wilkins, Inc.