Microvenular hemangioma (MVH) is an uncommon benign vascular neoplasm that usually occurs as a solitary asymptomatic red or purple papule, nodule, or plaque with a predilection for the upper extremities. Patients with more than 1 lesion, that is, multiple MVHs, are extremely rare. We describe the clinicopathologic features of 4 Chinese patients who had a rapidly progressive abrupt onset of numerous MVHs numbering in the tens to hundreds. Clinically, the correct diagnosis of MVH could not be made in any of our patients; however, histologic examination revealed the characteristic features of MVH. Immunohistochemical stains were performed in all cases and showed the vessel lining cells to be positive for CD34, CD31, and factor VIII-related antigen. Polymerase chain reaction for human herpesvirus-8 was negative in all cases. The differential diagnosis and review of the literature of patients with multiple MVHs are presented.
From the *Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China; †Nursing Department, Zhong Da Hospital Affiliated to Southeast University, Nanjing, China; and ‡Ackerman Academy of Dermatopathology, New York, NY.
Xiu-Lian Xu and Cui-Rong Xu contributed equally to this work.
Reprints: Jian-Fang Sun, MD, Xue-Si Zeng, BA, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing 210042, China (e-mail: firstname.lastname@example.org; email@example.com).