Skip Navigation LinksHome > June 2010 - Volume 32 - Issue 4 > Dermatopathic Lymphadenitis With Generalized Erythroderma in...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e3181b2a50f
Brief Report

Dermatopathic Lymphadenitis With Generalized Erythroderma in a Patient With Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Lee, Woo Jin MD; Lee, Deok Woo MD; Kim, Chae Hwa MD; Won, Chong Hyun MD; Chang, Sung Eun MD; Lee, Mi Woo MD; Choi, Jee Ho MD; Moon, Kee Chan MD

Collapse Box


Here, we describe a patient with Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) who simultaneously presented with generalized erythroderma and dermatopathic lymphadenitis (DL). A 63-year-old Korean woman presented at our hospital with fever, hepatosplenomegaly, axillary lymphadenopathy, and generalized erythrodermic eruption. The bone marrow biopsy findings were consistent with the diagnosis of HLH, and EBV DNA was detected using the polymerase chain reaction. Based on serologic tests that indicated a primary EBV infection, the patient was diagnosed with EBV-associated HLH. Histopathologic analysis of enlarged lymph nodes was consistent with DL, and EBV-encoded small nuclear RNA-positive mononuclear cells were detected. We assume that activated histiocytes, lymphocytes, and proinflammatory cytokines in HLH may have important roles in the development of generalized erythroderma and DL. Disrupted epidermal/dermal junctions owing to erythroderma may also be involved in the development of DL.

Copyright © 2010 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.