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Reticulated Acanthoma With Sebaceous Differentiation. Lack of Association With Muir-Torre Syndrome

Haake, Dana L MS3; Minni, John P DO; Nowak, Michael MD; Abenoza, Pascual MD; Nousari, Carlos H MD

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e318191cafc
Brief Report

We hereby report a case of a reticulated acanthoma with sebaceous differentiation (RASD), a rare and often mislabeled benign lesion that is characterized by epidermal acanthosis and clusters of sebocytes in a reticulated seborrheic keratosis-like pattern. The presence of multiple sebaceous tumors, most notably cystic sebaceous adenomas and keratoacanthomas, has been associated with Muir-Torre syndrome (MTS). Although very rare, cases of RASD have been reported with MTS, which potentially offers profound clinical significance to this neoplasm. This case further supports the lack of association of MTS with RASD.

Author Information

From the Dermpath Diagnostics South Florida, Pompano Beach, FL, USA.

Reprints: Dr. Carlos H Nousari, MD, Dermpath Diagnostics South Florida, Pompano Beach, FL, 33069, USA (e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.