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Primary Cutaneous Blastoid Mantle Cell Lymphoma-Case Report.

Estrozi, Bruna MD*; Sanches, José A Jr MD, PhD†; Varela, Paulo C S MD‡; Bacchi, Carlos E MD, PhD*

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31819d845a
Brief Report
Abstract

Mantle cell lymphoma (MCL) commonly involves extranodal sites, usually as a manifestation of disseminated disease. In rare cases, MCLs may arise as a primary tumor in the skin. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. The phenotype of BV-MCL is characterized as CD20+, CD5+, cyclin D1+, CD23, and CD10. Interphase fluorescence in situ hybridization shows a characteristic t(11;14) fusion pattern. We report a case of a BV-MCL arising in skin as primary cutaneous MCL with the characteristic immunophenotype and translocation.

Author Information

From the *Pathology Reference Laboratory, Botucatu, São Paulo, Brazil; †Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil; and ‡Clínica de Hematologia de São Paulo, São Paulo, Brazil.

Reprints: Carlos E. Bacchi, MD, PhD, Consultoria em Patologia, Rua Major Leônidas Cardoso, 739, Botucatu, São Paulo, 18602-010, Brazil (e-mail: bacchi@conspat.com.br).

© 2009 Lippincott Williams & Wilkins, Inc.