Skip Navigation LinksHome > June 2009 - Volume 31 - Issue 4 > Primary Cutaneous Blastoid Mantle Cell Lymphoma-Case Report.
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31819d845a
Brief Report

Primary Cutaneous Blastoid Mantle Cell Lymphoma-Case Report.

Estrozi, Bruna MD*; Sanches, José A Jr MD, PhD†; Varela, Paulo C S MD‡; Bacchi, Carlos E MD, PhD*

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Mantle cell lymphoma (MCL) commonly involves extranodal sites, usually as a manifestation of disseminated disease. In rare cases, MCLs may arise as a primary tumor in the skin. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. The phenotype of BV-MCL is characterized as CD20+, CD5+, cyclin D1+, CD23, and CD10. Interphase fluorescence in situ hybridization shows a characteristic t(11;14) fusion pattern. We report a case of a BV-MCL arising in skin as primary cutaneous MCL with the characteristic immunophenotype and translocation.

© 2009 Lippincott Williams & Wilkins, Inc.


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