Angiomatosis is defined as a hemangioma that affects a large segment of the body in a contiguous fashion, either by vertical extension to involve multiple tissue planes (eg, skin, subcutis, muscle, bone) or by crossing muscle compartments to involve similar tissue types (eg, multiple muscles). Such lesions usually present in the first 2 decades of life and have a highly characteristic but not totally specific histological pattern. Histology usually shows a haphazard mixture of small and medium-sized vessels, fat, connective tissue, and lymphatics. Large amounts of mature fat frequently accompany the vascular elements, suggesting that the lesion may possibly be a more generalized mesenchymal proliferation rather than an exclusively vascular lesion. Here we present what we believe to be the first case of angiomatosis showing osseous metaplasia.
From the *Department of Cellular Pathology, PathLinks Pathology Services, Lincoln County Hospital, Greetwell Road, Lincoln LN2 5QY, UK; and †Department of Obstetrics & Gynaecology, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Reprints: Nebojsa Neca Arsenovic, MD, Department of Cellular Pathology, PathLinks Pathology Services, Lincoln County Hospital, Greetwell Road, Lincoln LN2 5QY, UK (e-mail: firstname.lastname@example.org).