Vitiligo-like Primary MelanomaLugo-Somolinos, Aída MD*; Sánchez, Jorge L MD†; Garcia, María E MD†American Journal of Dermatopathology: October 2008 - Volume 30 - Issue 5 - pp 451-454 doi: 10.1097/DAD.0b013e318177a423 Extraordinary Case Report Abstract Author Information Depigmented or hypopigmented macules and patches have been described in association to primary and metastatic melanoma. Primary melanoma presenting at the onset as a vitiliginous patch without histopathological evidence of regression seems to be a rare event. We report 2 patients with melanoma in situ that expressed clinically as vitiligo-like patches and review the possible immunologic mechanisms responsible for this unusual presentation. *Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, NC; and †Department of Dermatology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico. Reprints: Jorge L. Sanchez, MD, Department of Dermatology, School of Medicine, University of Puerto Rico, PO Box 365067, San Juan, Puerto Rico 00936-5067 (e-mail: firstname.lastname@example.org). © 2008 Lippincott Williams & Wilkins, Inc.