Vitiligo-like Primary MelanomaLugo-Somolinos, Aída MD*; Sánchez, Jorge L MD†; Garcia, María E MD†American Journal of Dermatopathology: October 2008 - Volume 30 - Issue 5 - pp 451-454 doi: 10.1097/DAD.0b013e318177a423 Extraordinary Case Report Abstract Author Information Abstract Depigmented or hypopigmented macules and patches have been described in association to primary and metastatic melanoma. Primary melanoma presenting at the onset as a vitiliginous patch without histopathological evidence of regression seems to be a rare event. We report 2 patients with melanoma in situ that expressed clinically as vitiligo-like patches and review the possible immunologic mechanisms responsible for this unusual presentation. Author Information *Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, NC; and †Department of Dermatology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico. Reprints: Jorge L. Sanchez, MD, Department of Dermatology, School of Medicine, University of Puerto Rico, PO Box 365067, San Juan, Puerto Rico 00936-5067 (e-mail: firstname.lastname@example.org). © 2008 Lippincott Williams & Wilkins, Inc.