Skip Navigation LinksHome > October 2008 - Volume 30 - Issue 5 > Spiradenocylindroma-Like Basaloid Carcinoma of the Anus and...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31817fb37f
Extraordinary Case Report

Spiradenocylindroma-Like Basaloid Carcinoma of the Anus and Rectum: Case Report, Including HPV Studies and Analysis of the CYLD Gene Mutations

Kacerovska, Denisa MD, PhD*; Szepe, Peter MD†; Vanecek, Tomas PhD*; Nemcova, Jana MSc*; Michal, Michal MD*‡; Mukensnabl, Petr MD*; Kazakov, Dmitry V MD, PhD*

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The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman. Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes. The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium. A molecular biology study identified HPV-16 in the lesional tissue. Analysis of the CYLD gene did not prove any mutation.

© 2008 Lippincott Williams & Wilkins, Inc.


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