Skip Navigation LinksHome > October 2008 - Volume 30 - Issue 5 > Oral Lichenoid Lesions in HIV-HCV-Coinfected Subjects During...
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31817e23af
Extraordinary Case Report

Oral Lichenoid Lesions in HIV-HCV-Coinfected Subjects During Antiviral Therapy: 2 Cases and Review of the Literature

Giuliani, Michele MD, DDS*; Lajolo, Carlo PhD, MD, DDS*; Sartorio, Alessandra DDS*; Scivetti, Michele DDS, PhD†; Capodiferro, Saverio DDS†; Tumbarello, Mario MD‡

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Some dental materials and certain drugs may induce epithelial alterations, which clinically resemble oral lichen planus (OLP), on oral mucosa. But these alterations do not have all the clinical and/or the histological features of OLP; these lesions are known as oral lichenoid lesions (OLLs). Some researchers describe the onset and/or the worsening of OLL/OLP after the administration of anti-hepatitis C virus (HCV) therapy. In this article, we describe the development of symptomatic OLLs, as a consequence of anti-HCV therapy (interferon-α and ribavirine), in 2 human immunodeficiency virus-HCV-coinfected subjects. An immunological cause related to coinfection and administration of different medications could be responsible for the onset of OLLs. These new cases, together with the previous reports of a possible association between OLP and/or OLL and anti-HCV therapy, highlight the absolute need to monitor carefully the human immunodeficiency virus-HCV-coinfected subjects who are about to start the anti-HCV therapy and to define better the clinical and histopathological criteria to distinguish OLP from OLL.

© 2008 Lippincott Williams & Wilkins, Inc.


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