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Cutaneous Toxoplasmosis Histologically Mimicking Graft-Versus-Host Disease

Vidal, Claudia I MD, PhD*; Pollack, Margaret MD‡; Uliasz, Annemarie MD†; Toro, Gustavo del MD‡; Emanuel, Patrick O MD*

American Journal of Dermatopathology: October 2008 - Volume 30 - Issue 5 - pp 492-493
doi: 10.1097/DAD.0b013e3181837952
Extraordinary Case Report

The dermatology service is frequently consulted to assess cutaneous eruptions after hematopoietic stem cell transplantation. We describe a case of cutaneous toxoplasmosis in a stem cell transplant patient where toxoplasmosis trophozoites elicited a reaction pattern mimicking an interface dermatitis. At first blush, these findings may be misinterpreted as either a reaction to a drug or graft-versus-host disease. We hope that this case will prove helpful for dermatopathologists in asserting the correct diagnosis of cutaneous toxoplasmosis-if left untreated or treated incorrectly, this disease has a dismal prognosis.

From the *Division of Dermatopathology; and Departments of †Dermatology; and ‡Pediatric Oncology, Mount Sinai School of Medicine, New York, NY.

Reprints: Patrick O. Emanuel, MD, Division of Dermatopathology, Annenberg 3-08, Mount Sinai Hospital/School of Medicine, New York, NY 10029 (e-mail: patrick.emanuel@mssm.edu).

© 2008 Lippincott Williams & Wilkins, Inc.