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Hepatocellular Carcinoma Presenting as a Precocious Cutaneous Metastasis

Royer, Michael C MD*; Rush, Walter L MD†; Lupton, George P MD†

American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31815ea24f
Extraordinary Case Report

The authors report a case of hepatocellular carcinoma (HCC) diagnosed by evaluation of a cutaneous metastasis in a patient without a prior diagnosis of HCC. Subsequent evaluation confirmed the presence of additional widespread metastatic disease. The medical literature is reviewed with regards to cutaneous metastasis, including precocious metastasis, of HCC. The pathologic evaluation of HCC is reviewed, including a discussion of the immunohistochemical profile of this malignancy and the utility of hepatocyte paraffin 1, CD10, and polyclonal carcinoembryonic antigen (pCEA) immunohistochemical stains.

Author Information

From the *Department of Pathology and Area Laboratory Services, Walter Reed Army Medical Center, Washington, DC; and †Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC.

The authors report no financial relationships with any companies or products mentioned in this article.

The opinions and assertions presented herein are solely those of the authors and are in no way to be construed as the opinions or assertions of the United States Army or the Department of Defense.

Reprints: Michael C. Royer, MD, Department of Pathology and Area Laboratory Services, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Building 2, Ward 47, Washington, DC 20307 (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.