Granulomatous RosaceaSánchez, Jorge L MD; Berlingeri-Ramos, Alma C MD; Dueño, Dianette Vázquez MDAmerican Journal of Dermatopathology: February 2008 - Volume 30 - Issue 1 - pp 6-9 doi: 10.1097/DAD.0b013e31815bc191 Original Article Abstract Author Information Abstract Rosacea is classified into four clinical subtypes, namely erythematotelangiectatic, papulopustular, phymatous, and ocular. There is also a granulomatous variant, which is recognized in the rosacea spectrum. The objective of this study is to take a closer look at the different histopathologic patterns and cellular compositions seen in granulomatous rosacea and their correlation to the clinical presentation. Facial biopsies from patients previously identified with a clinical diagnosis consistent with rosacea, and who demonstrated a granulomatous infiltrate upon histopathologic examination, were reviewed and the results were correlated to the clinical presentation. Four distinct histopathologic granulomatous patterns were identified, namely nodular, perifollicular, diffuse, and a combined perifollicular and nodular patterns. The clinical presentation varied greatly among patients and failed to correlate to the microscopic findings. The varied clinical features seen in our study favors the theory that granulomatous rosacea is not a clinical subtype of rosacea per se, but a distinct histological variant, which can be found in most of its clinical spectrum. Author Information From the Department of Dermatology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico. The authors have no conflicts of interest to disclose. Reprints: Jorge L. Sánchez, MD, Department of Dermatology, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, Puerto Rico 00936-5067 (e-mail: email@example.com). © 2008 Lippincott Williams & Wilkins, Inc.