Skip Navigation LinksHome > February 2008 - Volume 30 - Issue 1 > CD117 Immunoreactivity in Atypical Fibroxanthoma
American Journal of Dermatopathology:
doi: 10.1097/DAD.0b013e31815b8ed5
Original Article

CD117 Immunoreactivity in Atypical Fibroxanthoma

Mathew, Rahel A MD*; Schlauder, Scott M MD†; Calder, Kenneth B MD*; Morgan, Michael B MD*†

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Abstract

Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the 16 cases (94%). The percentage of positive cells for CD117 expression among all tumors was approximately 30%. CD117 proved to be a very sensitive marker of AFX. This antibody may be a useful diagnostic adjunct in AFX.

© 2008 Lippincott Williams & Wilkins, Inc.

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