You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Reticulated Acanthoma With Sebaceous Differentiation

Fukai, Kazuyoshi MD; Sowa, Junko MD; Ishii, Masamitsu MD

American Journal of Dermatopathology:
doi: 10.1097/01.dad.0000199879.63857.dc
Extraordinary Case Reports
Abstract

Reticulated acanthoma with sebaceous differentiation (RASD) is characterized by the reticulated proliferation of spinous cells with aggregates of mature sebocytes in the bases of the strands of the keratinocytes, often linking rete ridges. Here, we report the first case reported as RASD. A 55-year-old woman presented with a 15-year history of a slightly pruritic patch on the upper back, and the histology was typical for RASD. She had been bothered by a yellow discharge from the tumor. Skin tumors with sebaceous differentiation are occasionally associated with Muir-Torre syndrome. However, immunohistochemical staining for mutS homolog 2 (MSH-2) and mutL homolog 1 (MLH-1) showed positive staining within the nuclei of sebaceous cells and cells in the dermis. Therefore, it is most likely that the present case is not associated with Muir-Torre syndrome.

Author Information

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan

Reprints: Kazuyoshi Fukai, MD, Department of Dermatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi Abenoku, Osaka 545-8585, Japan (e-mail: fukai@msic.med.osaka-cu.ac.jp)

© 2006 Lippincott Williams & Wilkins, Inc.