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Cutaneous Plasmacytosis: A Report of Five Cases with Immunohistochemical Evaluation for HHV-8 Expression

Jayaraman, Anu G. MD*; Cesca, Christine MD*; Kohler, Sabine MD* †

American Journal of Dermatopathology: April 2006 - Volume 28 - Issue 2 - pp 93-98
doi: 10.1097/01.dad.0000181107.08791.87
Original Articles

Cutaneous plasmacytosis is a rare disorder that typically affects middle-aged to older individuals of Asian, particularly Japanese, descent. Clinically, it is characterized by multiple asymptomatic red-brown plaques and nodules on the trunk. Lymphadenopathy and hypergammaglobulinemia may be present. Histologically, the lesions show a moderately dense superficial and deep perivascular infiltrate composed predominantly of mature plasma cells without atypia or light chain restriction. We report our experience with five additional cases, including results of immunohistochemical studies for human herpes virus 8.

*Department of Pathology, Stanford University, Stanford, CA

Department of Pathology, Stanford University, Stanford, CA

Reprints: Sabine Kohler, Department of Pathology – L235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324 (e-mail: skohler@stanford.edu).

© 2006 Lippincott Williams & Wilkins, Inc.