Skip Navigation LinksHome > June 2005 - Volume 27 - Issue 3 > Eccrine Syringofibroadenoma of Clear Cell Variant: An Immuno...
American Journal of Dermatopathology:
Extraordinary Case Report

Eccrine Syringofibroadenoma of Clear Cell Variant: An Immunohistochemical Study

Hu, Shasa MD*; Bakshandeh, Haleh MD*; Kerdel, Francisco A BSc, MBBS*†; Rongioletti, Franco MD‡; Romanelli, Paolo MD*†

Collapse Box

Abstract

Eccrine syringofibroadenoma is a rare eccrine tumor first described by Mascaro in 1963. The clear cell variant was reported by Fretzin in 1995. We describe a hemorrhagic papule on the knee of a 64-year-old woman. Microscopic examination revealed epidermal-based anastomosing thin epithelial cords with ductal structures surrounded by a fibrovascular stroma. Multiple nests of glycogen-containing clear cells were also present. The tumor cells forming the epithelial cords expressed keratin. The eccrine ductal structures and clear cells additionally expressed gross cystic disease fluid protein-15 (GCDFP-15). Reactivity with antibodies against estrogen receptor or progesterone receptor was negative. These results favor the dual differentiation of the clear cell variant of eccrine syringofibroadenoma toward ductal and secretory portions of the eccrine sweat gland.

© 2005 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.