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Cutaneous and Subcutaneous Fibrohistiocytic Tumors of Intermediate Malignancy: An Update

Billings, Steven D. MD*; Folpe, Andrew L. MD†

American Journal of Dermatopathology: April 2004 - Volume 26 - Issue 2 - pp 141-155
Review Article

Abstract: The fibrohistiocytic tumors of intermediate malignancy are uncommon mesenchymal tumors, which typically occur in the skin and subcutis and which may pose significant problems for the dermatopathologist. This article reviews the clinical, histopathologic, and genetic features of dermatofibrosarcoma protuberans, giant cell fibroblastoma, angiomatoid (malignant) fibrous histiocytoma, plexiform fibrous histiocytoma, and soft tissue giant cell tumor (of low malignant potential). The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed.

From the *Department of Pathology, Indiana University, Indianapolis, IN; and †Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.

Address correspondence and reprint requests to Andrew L. Folpe, MD, H-185 Emory University Hospital, 1364 Clifton Road, NE, Atlanta, GA 30322 (e-mail: afolpe@emory.edu).

© 2004 Lippincott Williams & Wilkins, Inc.